From a complex problem to a simple solution: The Ruma Marker-System.
Which is the correct matrix?
According to the Federal Health Gazette, studies have shown that urine is superior to saliva.
Annals of Clinical and Laboratory Research, 2022. Bernd Huppertz, Michael Bottcher, Stefan Lierheimer, Prisca Gottwald, Sergej Bleicher, Martin Schäfer. Download study as PDF
Innovations and up-to-date information
Paper "Matrixeffekte" | 2023
Matrix Effects of Urine Marker Substances in LC-MS/MS Analysis of Drug of Abuse
Paper "Telemedizinisches Verfahren zur Urinkontrolle bei Drogenabhängigkeit" | August 2023
Digital Monitoring of Adherence for Drug Abuse Treatment
Study | October 2023
Relapses in Illicit Drug Use Among Probationers: Results in a Risk Group of Public Health Services in Bavaria
Matrix comparison | June 2022
It all depends on the question! This study examines the strengths and weaknesses of urine, saliva and capillary blood in direct comparison.
Article Ärzteblatt | July 2020
"....One way to measure adherence in addiction therapy without contact is urine marker technology. It allows patients to provide urine samples without contact with a therapist..."
Article "Suchtmedizin" | September 2020
"However, those who use the system can benefit in several ways. There is no longer any need for visual checks that violate privacy, personal responsibility is increased and time is lost due to sometimes long journeys to and from the medical centers providing care."
We are the leading system regarding manipulation-proof and hassle-free urine analyses in addiction therapy and doping tests.
Since 2006 the Ruma Marker-System serves physicians, psychologists, correctional staff, probation officers and of course patients and subjects in therapy, withdrawal and occupational medicine by providing verified and transparent analysis results and facilitated office routines.




