Li­te­ra­ture on the Ru­ma® Mar­ker-Sys­tem

Quod est de­monstran­dum.

The Ru­ma Mar­ker-Sys­tem is a sci­en­ti­fic pro­ce­du­re, ve­ri­fied by nu­merous stu­dies and con­fir­med in va­rious ex­pert opini­ons. Sci­en­ti­fic backing is al­so pro­vi­ded in a vast num­ber of pu­bli­ca­ti­ons.

On this pa­ge we would li­ke to pro­vi­de an over­view of a ran­ge of pu­blis­hed li­te­ra­tu­re within the con­text of ap­pli­ca­ti­on of the Ru­ma Mar­ker-Sys­tem. He­re you can find both our own con­tent as well as in­for­ma­ti­on pro­vi­ded by ex­ter­nal con­tri­bu­ti­ons.

Sci­en­ti­fic li­te­ra­tu­re




Multiple scientific professional publications address the use and application of the Ruma® Marker-System. Here you find an overview of these papers, some of which we are making available as pdf downloads.



We have compiled a selection of scientific papers and expert opinions for you with information on the fundamental principles of the Ruma® Marker-System and other relevant topics all around drug analysis, doping tests and the various matrices.

Legal As­pec­ts of the Ru­ma Mar­ker-Sys­tem

The po­ly­ethy­le­ne gly­cols used by us find ap­pli­ca­ti­ons in many do­mains as car­ri­er sub­s­tan­ce, be­cau­se they are neit­her me­ta­bo­li­sed by the bo­dy nor do they re­act with other sub­s­tan­ces. They are


  • not me­di­ci­nes
  • not me­di­cal de­vices
  • not dia­gno­stic agents


Areas of ap­pli­ca­ti­on are, for ex­ample, cough sy­rup for child­ren or sports oint­ments.


From a legal perspective, this means the following:

  • No approval is required for a substance that cannot do anything and exhibits no activity beyond "just being there". Various national and international authorities have confirmed this in writing. This includes EMA at the European level and FDA/CDER for the USA.
  • Statements on the applicability of the Ruma Marker-System have also been issued for the following countries:




Great Britain

The Netherlands




  • The sa­me ap­plies to CE mar­king - so­me­thing we are as­ked about of­ten.
  • Sin­ce our PEGs don't do any­thing and have no abi­li­ties, they are not sub­ject to laws that for­bid in­ter­ven­ti­on with bo­dy func­tions du­ring drug tes­ting or make such in­ter­ven­ti­ons de­pen­dent on con­sent by the per­son to be tested. You can find mo­re in­for­ma­ti­on about this un­der our sec­tion Pe­nal Sys­tem and Pro­ba­ti­on Ser­vices.
  • With pregnant pa­ti­ents, the de­cis­i­on of whe­ther using the mar­ker is in­di­ca­ted lies with the trea­ting phy­si­ci­an.


Our state­ment of no ob­jec­tion re­gar­ding the po­ly­ethy­le­ne gly­cols we use in­clu­des all re­le­vant in­for­ma­ti­on on the le­gal clas­si­fi­ca­ti­on of the sub­s­tan­ces.


State­ment of no ob­jec­tion