The Mar­ker-Sys­tem

The Ru­ma Mar­ker-Sys­tem of­fers ma­xi­mum safe­ty and pro­tec­tion against ma­ni­pu­la­ti­on at­tempts in uri­ne tes­ting.

Ma­ni­pu­la­ti­on at­tempts in uri­ne tes­ting are a com­mon pro­blem. The­re are nu­merous ways to try and achie­ve a fal­se-ne­ga­ti­ve re­sult.

The Ru­ma Mar­ker-Sys­tem ad­dres­ses this pro­blem and en­su­res that the uri­ne sam­ple to be tested ori­gi­na­tes from the right per­son and is availa­ble in the ap­pro­pria­te qua­li­ty. 

The practical application is simple and can be integrated easily into the existing routines. The key to our success lies in our quality controlled pre-analytical procedures and precise laboratory analysis in accordance with state-of-the-art science and technology.

Ru­ma Mar­ker-Sys­tem pro­ducts

The Ruma Marker-System is not a static product. It develops based on new insights gained during practical application and the current state of scientific knowledge. Hence, in addition to the classic liquid markers, the marker capsule as well as other security aspects is now available. The marker capsule can be complemented using Ruma Digital-System.

Ru­ma® Di­gi­tal-Sys­tem 

 

Lo­ca­ti­on in­de­pen­dent uri­ne scree­ning. With-out an ap­point­ment - any time! 

Mo­re in­for­ma­ti­on

Ru­ma® Cap­su­le

 

The next ge­ne­ra­ti­on of the Mar­ker-Sys­tem.

Mo­re in­for­ma­ti­on

Ru­ma® Clas­sic

 

The re­lia­ble al­ter­na­ti­ve to con­ven­tio­nal di­rect ob­ser­va­ti­on!

More information

Fields of application

 

The Ru­ma Mar­ker-Sys­tem en­su­res the identity and quality of the tested uri­ne sam­ple. Two as­pects, which are of gre­at im­por­tan­ce for many areas of ap­pli­ca­ti­on. 

For ex­ample, the Ru­ma Mar­ker Sys­tem is used in:

Clinical application of the urine marker solution

The application of the Ruma® Marker-System using the example of the liquid marker Ruma® Classic

The Ruma Markers we use are polyethylene glycols – also called macrogols – which only pass through the body due to their specific properties and are excreted unchanged through the urinary bladder. We use this complete lack of effect to mark the patient's urine sample without any risk or possible interaction with other substances and thus to prove the identity of the urine donor.

 

At present, we use 6 different marker substances that present very distinct analytical results. As neither the patient nor the physician are aware which marker is administered in any given situation, the swapping of already marked urine samples is also easily detectable.

 

Under normal circumstances the marker requires 30 minutes to reach the bladder naturally. In rare cases, 1:250,000, a slightly longer waiting period is required for delayed urination.

Mix the mar­ker sub­s­tan­ce with a be­ver­age swee­te­ned with re­gu­lar hou­se­hold su­gar and have the pa­ti­ent drink the mix right in front of you. The pa­ti­ent can collect the sam­ple on their own af­ter at least 40 mi­nu­tes.

 

The collec­ted uri­ne sam­ple is then pre­pa­red for trans­port to one of our au­tho­ri­zed part­ner labs. You will re­cei­ve the re­sults through elec­tro­nic com­mu­ni­ca­ti­on or by fax.

 

We developed the capsule as an alternative administration form for the well-known Ruma® marker substances. In addtion to the established PEGs it containes the colorant Brilliant Blue. If the capsule remains in the mouth too long, e.g. for the purpose of manipulation, it dissolves and releases the dye: the mouth cavity turns blue. This makes oral cavity checking much easier and there's no need to add sugar as is done with the liquid markers.

The ana­ly­sis of the Ru­ma mar­kers.

 

The Mar­ker Ana­ly­sis de­ter­mi­nes whe­ther the uri­ne sam­ple con­tains the ad­mi­nis­te­red mar­ker and whe­ther it is pre­sent in suf­fici­ent quan­ti­ty. Com­ple­te ab­sence of the mar­ker is an in­di­ca­ti­on of sam­ple sub­sti­tu­ti­on. Ve­ry litt­le mar­ke vo­lu­me sug­gests di­lu­ti­on. This ap­plies to di­lu­ti­on with “cle­an” uri­ne as well. The Ru­ma Mar­ker-Sys­tem is mo­re than just the se­arch for the ad­mi­nis­te­red mar­ker. We use 4 pil­lars to test the uri­ne samp­les for ma­ni­pu­la­ti­on from all per­spec­ti­ves:
 

Mar­ker ana­ly­sis, Crea­ti­ni­ne ana­ly­sis, Glu­co­se ana­ly­sis, Sam­ple in­te­gri­ty ana­ly­sis

(Test for oxi­dan­ts/sam­ple check, syn­the­ti­c uri­ne

Why urine?

Uri­ne samp­les are of­ten sub­ject to va­rious ma­ni­pu­la­ti­on at­tempts. This is a well-known and of­ten bemo­aned pro­blem.

 

That's why scientific research has been looking for quite some time for an alternative that might be less susceptible to such manipulations. Below we would like to show why urine is still the matrix of choice by investigating two such alternatives.

 

Much more pressing in the current situation, however, is the question how the risk of infection during collection of urine samples can be minimized.

Numerous addiction treatment facilities are already closed, and it has become a challenge to ensure health care for patients in MAT. Because addiction patients face an extreme risk due to comorbidities.

 

In order to alleviate the pressure treatment facilities are facing, take home is used as an alternative. This is where the app package Ruma® Digital System and Ruma® Digital System Pro can help to keep communication between doctor and patient in tact. It allows location independent urine testing and reduces the number of necessary visits to the medical office.